Entertainment websites E! News, TMZ and Variety first reported on the split and it was later confirmed by the Associated Press.
TMZ said sources called the divorce “amicable,” saying Kardashian is asking for joint legal and physical custody of the couple’s four children, which the rapper is “fine” with.
It follows months of speculation that the couple’s marriage was in trouble, with multiple sources close to the couple telling US media that their “divorce is imminent” and Kardashian hiring renowned divorce attorney Laura Wasser.
Kardashian, who shot to fame in the reality TV show Keeping Up with the Kardashians with her family, married Gold Digger hitmaker West in May 2014, making them one of the biggest celebrity couples in Hollywood.
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Their marriage is believed to have hit the rocks last year when West, 43, who suffers from bipolar disorder, ran an unsuccessful US presidential campaign marked by erratic statements under his self-styled Birthday Party.
In July, Kardashian defended West’s behaviour in a statement urging compassion for his mental struggles.
However, the couple appeared to continue to grow apart with the 21-time Grammy winner spending most of his time at his ranch in Wyoming, while Kardashian resided in their Calabasas mansion outside Los Angeles.
The couple married in Italy in 2014 and have four young children: North, Saint, Chicago and Psalm.
It was the first marriage for the 43-year-old West, and the third for the 40-year-old Kardashian.